Database
Protein sequence database for pathogenic arenaviruses
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* Corresponding author: Alessandro Sette alex@liai.org
1 La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, 9420 Athena Circle, La Jolla, CA 92037, USA
2 The Scripps Research Institute, Molecular & Integrative Neurosciences Department, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
3 California State University, Department of Biology, San Marcos, CA 92096, USA
Immunome Research 2007, 3:1 doi:10.1186/1745-7580-3-1
Published: 8 February 2007Abstract
Background
Arenaviruses are a family of rodent-borne viruses that cause several hemorrhagic fevers. These diseases can be devastating and are often lethal. Herein, to aid in the design and development of diagnostics, treatments and vaccines for arenavirus infections, we have developed a database containing protein sequences from the seven pathogenic arenaviruses (Junin, Guanarito, Sabia, Machupo, Whitewater Arroyo, Lassa and LCMV).
Results
The database currently contains a non-redundant set of 333 protein sequences which were manually annotated. All entries were linked to NCBI and cited PubMed references. The database has a convenient query interface including BLAST search. Sequence variability analyses were also performed and the results are hosted in the database.
Conclusion
The database is available at http://epitope.liai.org:8080/projects/arena webcite and can be used to aid in studies that require proteomic information from pathogenic arenaviruses.