Database

Protein sequence database for pathogenic arenaviruses

Huynh-Hoa Bui¹ , Jason Botten² , Nicolas Fusseder¹ , Valerie Pasquetto¹ , Bianca Mothe³ , Michael J Buchmeier² and Alessandro Sette¹

¹  La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, 9420 Athena Circle, La Jolla, CA 92037, USA

²  The Scripps Research Institute, Molecular & Integrative Neurosciences Department, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

³  California State University, Department of Biology, San Marcos, CA 92096, USA

author email corresponding author email

Immunome Research 2007, 3:1doi:10.1186/1745-7580-3-1

Published:	8 February 2007

Abstract

Background

Arenaviruses are a family of rodent-borne viruses that cause several hemorrhagic fevers. These diseases can be devastating and are often lethal. Herein, to aid in the design and development of diagnostics, treatments and vaccines for arenavirus infections, we have developed a database containing protein sequences from the seven pathogenic arenaviruses (Junin, Guanarito, Sabia, Machupo, Whitewater Arroyo, Lassa and LCMV).

Results

The database currently contains a non-redundant set of 333 protein sequences which were manually annotated. All entries were linked to NCBI and cited PubMed references. The database has a convenient query interface including BLAST search. Sequence variability analyses were also performed and the results are hosted in the database.

Conclusion

The database is available at http://epitope.liai.org:8080/projects/arena webcite and can be used to aid in studies that require proteomic information from pathogenic arenaviruses.