Table 1

Performances of the individual prediction tools on the HLA-A*0201 peptides from the community binding resource.
Tool
 AROC
 0.99 Specificity
 0.95 Specificity




Rank1
 Sensitivity
 Threshold2
 Rank
 Sensitivity
 Threshold
ARB Matrix
 0.935
 4
 0.188
 2.190
 2
 0.601
 42.950
NetMHC 2.0 ANN
 0.932
 1
 0.286
 153.000
 1
 0.611
 920.000
SMM
 0.922
 2
 0.201
 38.092
 4
 0.543
 454.865
Bimas
 0.920
 3
 0.198
 324.068
 3
 0.552
 47.991
SYFPEITHI
 0.885
 8
 0.170
 27.000
 5
 0.421
 24.000
Multipred ANN
 0.884
 9
 0.140
 5.820
 7
 0.373
 5.560
NetMHC 2.0 Matrix
 0.872
 6
 0.177
 24.329
 10
 0.358
 20.129
SVMHC MHCPEP
 0.870
 12
 0.115
 1.000
 11
 0.334
 0.520
Logistic Regression
 0.862
 13
 0.101
 0.364
 9
 0.364
 0.108
SVMHC SYFPEITHI
 0.854
 7
 0.176
 0.950
 8
 0.367
 0.490
HLA Ligand
 0.825
 10
 0.137
 141.000
 14
 0.274
 127.000
Rankpep
 0.822
 15
 0.077
 103.000
 13
 0.306
 83.000
MHCPred (Interactions)
 0.818
 5
 0.182
 43.350
 6
 0.377
 99.080
MHCPred (position only)
 0.814
 11
 0.116
 21.330
 12
 0.311
 65.310
Multipred HMM
 0.798
 14
 0.090
 7.530
 15
 0.244
 7.090
Predep
 0.788
 16
 0.045
 -6.000
 16
 0.217
 -5.130

The predictive performance of each tool for the HLA-A*0201 community binding data is shown using two measures: AROC score, and sensitivity when specificity is 0.99 and 0.95. 1Indicates how the sensitivity of each tool compares to that of the other tools at the indicated specificity; the tool with rank 1 has the highest sensitivity. 2The scoring threshold corresponding to the indicated specificity.

Trost et al. Immunome Research 2007 3:5   doi:10.1186/1745-7580-3-5