Table 4

Individual tool AROC values and sensitivity data for HLA-A*0201 using binders and nonbinders gathered from the literature
Tool
 AROC
 0.99 Specificity
 0.95 Specificity




Rank
 Sensitivity
 Threshold
 Rank
 Sensitivity
 Threshold
Multipred ANN
 0.772
 11
 0.083
 5.830
 2
 0.278
 5.600
NetMHC 2.0 ANN
 0.772
 6
 0.139
 99.000
 7
 0.231
 300.000
SYFPEITHI
 0.762
 1
 0.194
 27.000
 2
 0.278
 25.000
SVMHC MHCPEP
 0.745
 1
 0.194
 0.910
 4
 0.269
 0.740
Logistic Regression
 0.743
 10
 0.093
 0.424
 12
 0.167
 0.281
ARB Matrix
 0.742
 8
 0.102
 1.860
 14
 0.139
 3.550
Bimas
 0.722
 12
 0.074
 437.482
 9
 0.213
 159.970
NetMHC 2.0 Matrix
 0.719
 14
 0.046
 27.193
 10
 0.194
 23.585
SMM
 0.716
 4
 0.157
 100.484
 6
 0.250
 262.434
Rankpep
 0.708
 3
 0.176
 89.000
 5
 0.259
 83.000
MHCPred (interactions)
 0.707
 6
 0.139
 61.660
 1
 0.287
 100.690
SVMHC SYFPEITHI
 0.706
 5
 0.148
 0.970
 11
 0.185
 0.820
HLA Ligand
 0.705
 12
 0.074
 147.000
 12
 0.167
 138.000
MHCPred (position only)
 0.700
 8
 0.102
 28.250
 7
 0.231
 67.300
Multipred HMM
 0.695
 16
 0.009
 7.570
 15
 0.102
 7.290
Predep
 0.627
 15
 0.019
 -6.450
 16
 0.093
 -5.330

For details, see the caption for Table 1. The peptides in this literature-derived dataset are available in Additional File 1.

Trost et al. Immunome Research 2007 3:5   doi:10.1186/1745-7580-3-5