IDR knowledge base for primary immunodeficiencies

doi:10.1186/1745-7580-3-6

Immunome Research

Volume 3

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Väliaho J
Vihinen M

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IDR knowledge base for primary immunodeficiencies

Crina Samarghitean¹ , Jouni Väliaho¹ and Mauno Vihinen¹^,2

¹Institute of Medical Technology, FI-33014 University of Tampere, Finland

²Research Unit, Tampere University Hospital, FI-33520 Tampere, Finland

author email corresponding author email

Immunome Research 2007, 3:6doi:10.1186/1745-7580-3-6


Published:	29 March 2007

Abstract

Background

The ImmunoDeficiency Resource (IDR) is a knowledge base for the integration of the clinical, biochemical, genetic, genomic, proteomic, structural, and computational data of primary immunodeficiencies. The need for the IDR arises from the lack of structured and systematic information about primary immunodeficiencies on the Internet, and from the lack of a common platform which enables doctors, researchers, students, nurses and patients to find out validated information about these diseases.

Description

The IDR knowledge base, first released in 1999, has grown substantially. It contains information for 158 diseases, both from a clinical as well as molecular point of view. The database and the user interface have been reformatted. This new IDR release has a richer and more complete breadth, depth and scope. The service provides the most complete and up-to-date dataset. The IDR has been integrated with several internal and external databases and services. The contents of the IDR are validated and selected for different types of users (doctors, nurses, researchers and students, as well as patients and their families). The search engine has been improved and allows either a detailed or a broad search from a simple user interface.

Conclusion

The IDR is the first knowledge base specifically designed to capture in a systematic and validated way both clinical and molecular information for primary immunodeficiencies. The service is freely available at http://bioinf.uta.fi/idr and is regularly updated. The IDR facilitates primary immunodeficiencies informatics and helps to parameterise in silico modelling of these diseases. The IDR is useful also as an advanced education tool for medical students, and physicians.