Table 3

GPCRs induced by LPS in macrophages.



Relative Normalised Expression



Receptor Class
 Accession Number
 Gene Name
 BMM
 TEPM






2 h
 6 h
 24 h
 1 h
 7 h
Induced by LPS in BMM and TEPM
Class A







NM_009630
 Adora2a
 1.2
 28.2
 3.3
 4.2
 52.2

NM_007413
 Adora2b
 27.4
 190.9
 17.4
 3.0
 3.3

NM_007719
 Ccr7
 1.0
 5.1
 1.9
 0.4
 2.9

NM_017466
 Ccrl2
 39.2
 65.7
 46.7
 13.8
 9.2

NM_010336
 Edg2
 7.3
 5.7
 0.3
 1.0
 10.0

NM_007904
 Ednrb
 6.7
 2.0
 10.3
 0.7
 5.3

NM_013521
 Fpr1
 5.9
 120.9
 23.3
 1.0
 21.4

NM_008042
 Fprl1
 3.8
 41.6
 28.6
 3.1
 570.6

NM_030701
 Gpr109b
 13.6
 48.2
 5.6
 10.8
 212.0

NM_030720
 Gpr84
 8.7
 10.3
 0.2
 7.8
 47.5

NM_145066
 Gpr85
 3.6
 5.6
 0.5
 18.1
 4.9
Class B







NM_018782
 Calcrl
 1.0
 2.6
 0.2
 0.6
 6.9
Frizzled







NM_021457
 Fzd1
 8.0
 17.0
 1.0
 1.0
 2.2
Induced by LPS in BMM
Class A







NM_009912
 Ccr1
 0.9
 3.1
 7.4
 0.8
 0.7

NM_009911
 Cxcr4
 0.3
 0.1
 7.2
 0.7
 0.1

NM_004230
 Edg5
 0.2
 0.5
 2.0
 0.4
 0.6

NM_182806
 Gpr18
 17.8
 52.2
 10.8
 1.0
 1.6

NM_175493
 Gpr68
 3.3
 1.7
 40.2
 1.5
 0.8

NM_013533
 Gpr162
 1.1
 0.5
 6.7
 0.8
 0.8

NM_008311
 Htr2b
 0.6
 0.5
 15.8
 0.6
 0.3

NM_008519
 Ltb4r1
 0.8
 0.8
 7.5
 0.9
 0.7

NM_008773
 P2ry2
 3.7
 7.5
 3.7
 1.9
 1.1

NM_021381
 Prokr1
 0.8
 37.4
 7.2
 0.3
 0.1

NM_008964
 Ptger2
 2.4
 1.3
 11.7
 0.3
 0.1

NM_008967
 Ptgir
 1.1
 2.3
 7.4
 0.7
 0.6
Class B







NM_139138
 Emr4
 1.1
 2.0
 1.0
 1.0
 0.9

NM_001081298
 Lphn2
 2.2
 1.4
 1.2
 0.3
 0.3
Induced by LPS in TEPM
Class A







NM_007577
 C5r1
 1.1
 0.7
 0.1
 3.0
 1.1

NM_007722
 Cxcr7
 0.5
 0.5
 0.5
 1.0
 4.0

NM_133200
 P2ry14
 0.7
 1.7
 1.4
 0.8
 6.7

Micro-array analysis was used to assess the gene expression profile of GPCRs upon LPS treatment in primary mouse macrophages (BMM and TEPM). GPCRs regulated by LPS in primary mouse macrophages were defined as those that were 2-fold or greater up-regulated at 2, 6 or 24 h LPS in BMM and/or 1 or 7 h LPS in TEPM (and significantly different from controls, p-value < 0.05, Student's two-tailed t-test). Values shown depict gene expression relative to untreated control (0 h). GPCRs are grouped according to their class type on the basis of sequence similarity as previously described [65-67].

Lattin et al. Immunome Research 2008 4:5   doi:10.1186/1745-7580-4-5