Figure 4.

The identified arenavirus-specific CD4⁺ T cell epitopes provide broad population coverage. The theoretical population coverage was calculated based on the binding affinity data for each HLA-DRB1-restricted epitope and the reported frequencies of each HLA-DRB1 allele in different ethnic populations. Biologically relevant binding was defined as an IC₅₀ ≤ 200 nM. (A) The average population coverage for each of the 7 arenaviruses. The horizontal dashed line indicates that 82.6% of the population, on average, recognizes one or more arenavirus epitope. (B) For GTOV, shown as representative data, the number of possible peptide-HLA allele combinations as a function of the fraction of each ethnic population (%) is shown. The horizontal dashed line represents the fraction of individuals (92.3%) that recognize one or more GTOV peptide in an average population.