Table 2 |
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|
Number of HLA-DRB1, DRB3, DRB4, and DRB5 molecules bound by the arenavirus-specific CD4+ T cell epitopes. |
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|
Epitopea |
No. DRB1 molecules boundb |
No. DRB3/4/5 molecules boundc |
Total No. DR molecules bound |
|
|
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|
GTOV GPC131-145 |
4 |
1 |
5 |
|
GTOV L181-195 |
3 |
1 |
4 |
|
GTOV L391-405 |
9 |
1 |
10 |
|
GTOV L1826-1840 |
8 |
2 |
10 |
|
GTOV NP166-180 |
8 |
1 |
9 |
|
GTOV NP191-205 |
8 |
2 |
10 |
|
GTOV NP236-250 |
10 |
1 |
11 |
|
GTOV NP541-555 |
9 |
2 |
11 |
|
JUNV GPC46-60 |
6 |
1 |
7 |
|
JUNV L381-395 |
10 |
3 |
13 |
|
JUNV L391-405 |
8 |
1 |
9 |
|
JUNV L411-425 |
6 |
1 |
7 |
|
JUNV L1491-1505 |
8 |
2 |
10 |
|
JUNV L1711-1725 |
8 |
1 |
9 |
|
LASV GPC236-250 |
7 |
2 |
9 |
|
LASV GPC241-255 |
7 |
1 |
8 |
|
LASV GPC476-490 |
1 |
1 |
2 |
|
LCMV GPC421-435 |
6 |
2 |
8 |
|
LCMV L256-270 |
3 |
1 |
4 |
|
LCMV L946-960 |
8 |
3 |
11 |
|
LCMV NP6-20 |
7 |
2 |
9 |
|
LCMV NP521-535 |
5 |
2 |
7 |
|
MACV GPC96-110 |
3 |
1 |
4 |
|
MACV GPC251-265 |
8 |
2 |
10 |
|
MACV GPC446-460 |
2 |
1 |
3 |
|
MACV L391-405 |
7 |
1 |
8 |
|
MACV L636-650 |
10 |
3 |
13 |
|
MACV L866-880 |
7 |
2 |
9 |
|
MACV L1491-1505 |
9 |
3 |
12 |
|
MACV L1711-1725 |
8 |
1 |
9 |
|
MACV NP191-205 |
8 |
2 |
10 |
|
MACV Z21-35 |
8 |
2 |
10 |
|
SABV GPC26-40 |
7 |
2 |
9 |
|
SABV GPC436-450 |
5 |
1 |
6 |
|
SABV GPC441-455 |
7 |
1 |
8 |
|
WWAV GPC46-60 |
5 |
1 |
6 |
|
WWAV GPC386-400 |
6 |
2 |
8 |
|
|
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|
a Peptide position within the GPC, L, NP, or Z protein of prototypic strains of GTOV, JUNV, LASV, LCMV, MACV, SABV, and WWAV. b Each epitope was tested for binding to 14 common HLA molecules within the DR supertype. The number of HLA molecules bound corresponds to the epitope having an IC50 ≤ 200 nM to the specific HLA molecule. c The number of DRB3*0101, DRB4*0101, and DRB5*0101 molecules bound by the arenavirus epitopes with an IC50 ≤ 200 nM. |
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Kotturi et al. Immunome Research 2010 6:4 doi:10.1186/1745-7580-6-4 |
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